Codeine is a prescription opioid that is often combined with other drugs to increase its effectiveness. Paracetamol, also known as acetaminophen, is one such drug that is commonly combined with codeine. This combination boosts codeine’s pain-relieving effects, but there are certain risks to consider when taking this prescription medication.
The following overview explores paracetamol and codeine combinations and the potential side effects and risks these drugs can create.
What Is Codeine?
Codeineis a relatively mild prescription opioid that canhelp treat moderate pain and cough. In some cases, it may also be used to treat diarrhea. Codeine may bemild compared to other opioids, but it’s still acontrolled substancethat carries the risks of physicaldependence and addiction.
When someone takes codeine, itconverts into morphineand then binds to opioid receptors in the body. This suppresses a person’s cough reflex, reduces sensations of pain and depresses the central nervous system.
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Like other opioids, codeine can trigger a flood of certain neurotransmitters in the brain andcause a euphoric highin some people, particularly when larger doses are taken. This is one of the reasons why codeine can be addictive, but the risk of addiction is lower when you take it for a short period and as prescribed.
What Is Paracetamol?
Paracetamol, oracetaminophen, is an over-the-counter drug used in brand-name medications like Tylenol. Paracetamol treats mild to moderate pain caused by conditions like backaches and headaches. It’s one of the most commonly used pain relievers in the world, and there are many brands of paracetamol available. Paracetamol is often used in combination with other pain relievers and drugs to boost effectiveness.
As long as dosage instructions are followed, paracetamol is considered a safe medicine. However, paracetamol cancause liver damagewhen large amounts are used. This can also occur when people who are predisposed to liver problems use paracetamol.
Paracetamol and Codeine
Codeine is often combined with other drugs, including paracetamol, to improve its effectiveness as a pain reliever. When paracetamol and codeine are combined, however, there are certain risks to be aware of.
Together, paracetamol and codeine can be potentially dangerous. This is partly due to the addictive opioid component, but also because paracetamol can cause liver damage or acute liver failure if more than a certain dosage is taken in a 24-hour period.
Codeine and Paracetamol Tablets
Codeine and paracetamol tablets are available as drugs likeTylenol with Codeine #3andTylenol with Codeine #4. Some tablets also contain other substances, such as caffeine. Codeine and paracetamol tablets can be prescribed for a variety of reasons, including headaches, migraines and pain related to dentistry, surgery or accidents.
Codeine and paracetamol tablets are only recommended for people who areat least 12 years old. Since they contain paracetamol, it’s important to follow dosing instructions very carefully to avoid liver damage. Codeine and paracetamol tablets shouldn’t be used for more than five days in a row unless directed by a doctor.
Paracetamol and Codeine Phosphate
Codeine is available as either codeine sulfate and codeine phosphate. The difference in the name simply refers to the chemical process used to create it. The following side effect information and dosage guidelines apply to both types of codeine.
Paracetamol and Codeine Side Effects
Most of the potential side effects of a paracetamol and codeine combination are caused by the codeine. Common side effects caninclude:
- Itching
- Nausea
- Drowsiness
- Constipation
- Lightheadedness
- Dizziness
Severe but uncommon paracetamol and codeine side effects caninclude:
- Mood or mental changes
- Severe abdominal pain
- Vision changes
- Problems urinating
- Fainting
- Liver damage or acute liver failure
People who take paracetamol and codeine may also feel high due to how the codeine impacts the brain. It is possible to abuse or become addicted to this drug, but the risk is lower when you follow dosing instructions.
If you take too much, it can slow respiration to a dangerous level orcause a potentially fatal overdose. Most people don’t have serious side effects as long as they use the drug as directed by their doctor.
Paracetamol and Codeine Dosage
When a physician determines a paracetamol and codeine dosage, they look at individual factors like liver functionality, age and opioid tolerance. However, some general dosage guidelines can be used. Usually, paracetamol and codeineis dosed as:
- Codeine 30 mg and paracetamol 300 mg every four hours as needed for pain
- Codeine 60 mg and paracetamol 300 mg every four hours as needed for pain
- Codeine 60 mg and paracetamol 600 mg every four hours as needed for pain
These are just rough guidelines and should never be used instead of your doctor’s advice.
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Dosage Guidelines:
- The paracetamol codeine dosage for the oral liquid form of the drug is 15 mL every four hours as needed for adults
- For children ages 7 to 12 taking the liquid, it’s 10 mL 3 or 4 times a day, and for children ages 3 to 6 it’s 5 mL 3 or 4 times a day
- For tablet paracetamol codeine dosages, it’s 1 to 2 tablets every four hours as needed for pain in adults, and child dosages have to be determined by a doctor.
These are just rough guidelines and should never be used instead of your doctor’s advice.
